Are Neurons Just Too Laissez-Faire about Repair?

• 1 Comment

24 Jul 2003

do not efficiently repair the bulk of their genome (see, for example, Gobbel et al., 1998). Neurons

How Does Excess Aβ Leave the Brain, How Does It Get In, And Can We Trap It Outside?

• 1 Comment

23 Jun 2003

hypothesis of Ab and related Ab-lowering strategies in more breadth and detail. Synposis of Deane et al

Axonal Transport Hypothesis Moves On to Implicate Presenilin

• 1 Comment

17 Jun 2003

(Cai et al., 2002; Naruse et al., 1998; ARF related news story). One way in which PS1 might modulate

Cholinergic Plasticity in Hippocampus of Individuals with Mild Cognitive Impairment: Correlation with Alzheimer's Neuropathology

19 May 2003

caused the sprouting. See our paper in J Neuroscience in November (Sheng et al., 2002). Milos Ikonomovic

Protein Folding and Neurodegeneration: Biophysics to the Rescue?

30 Apr 2003

oligomerize and polymerize out of lipid environment, to self- and cross-associate (Koudinov et al., 1998

RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

18 Mar 2003

1992; Cogoni et al., 1996). Since its first description in animal cells (Fire et al., 1998), a growing

CAA: We All Know It's There, But Just What Is It Doing in Alzheimer's?

12 Mar 2003

al., 2000; Weller et al., 1998). Moreover, in transgenic mice, virtually identical amyloid-associated

Probing PPARγ? Agonists: Could Diabetes Drugs Treat Alzheimer's Disease?

• 1 Comment

16 Dec 2002

Jiang et al., 1998), together with the commercial availability of PPARγ agonists, has raised interest in

Intraneuronal Aβ Accumulation—More Evidence, Less Controversy?

• 1 Comment

26 Nov 2002

out there! (See Jaworska-Wilczynska et al., 2002.) Jorge Busciglio Gunnar, you see particularly

Cholesterol and Alzheimer's—Charging Fast But Still at a Distance from Solid Answers

• 3 Comments

19 Nov 2002

paper by Fassbinder (Fassbinder et al., 2002) on no change in Aβ after statin treatment. Tobias Hartmann

How the Other Half Lives—Or the What, How, and Where of the AβPP Intracellular Domain

• 1 Comment

20 Sep 2002

One paper showed Ab to bind to APP. Does this seem reasonable? (See Lorenzo, et al., Nature Neurosci

β Amyloid Degradation: The Forgotten Half of Alzheimer's Disease

• 7 Comments

12 Sep 2002

activity was attributable to a 110 kDa protease that was later shown to be IDE (Qiu et al., 1998

The Cell Cycle and Alzheimer’s Disease—Let's Unite for Division!

• 6 Comments

07 Aug 2002

Lin et al., 2001. We have shown that exposure to toxic injuries, such as free radicals, leads to

From Here to There: AβPP as an Axonal Transport Receptor—How Could This Explain Neurodegeneration in AD?

15 Jul 2002

Ashford, Soultanian, et al., 1999. We did not examine axons. However, this discussion seems to be focusing

Alzheimer Genes in Cortical Development: How Do Their Prenatal Functions Relate to Dementia?

12 Jul 2002

Mice lacking both PS1 and PS2 die before embryonic day 9 (Donoviel et al., 1999). PS1-/- mice, which